Anonīma ārsta vēstule kolēģiem par masu vakcinācijas pret Covid-19 neviennozīmīgumu

Cienījamie kolēģi, ar šo jūsu steidzamai uzmanībai ir nodotas četras nesenas zinātniskas atziņas. Tās maina visu Covid-19 pandēmijas ainavu, un tās liek mums pārvērtēt vakcinācijas pret SARS-CoV-2 priekšrocības.

KOPSAVILKUMS

Ātra un efektīva atmiņas tipa imūnreakcija rodas faktiski visiem nevakcinētiem indivīdiem, kuri ir pakļauti SARS-CoV-2 iedarbībai. Tāpēc ir ļoti apšaubāma imūnsistēmas atbildes reakcijas turpmākas palielināšanas efektivitāte, veicot vakcināciju. Tā vietā vakcinācija var pastiprināt slimību, izsaucot autoimūno reakciju (ADE – Antibody-dependent enhancement).

1. ATKLĀJUMS

SARS-CoV-2 smailes proteīns nonāk asins cirkulācijā neilgi pēc vakcinācijas. SARS-CoV-2 proteīni tika mērīti gareniskajos plazmas paraugos, kas savākti no 13 dalībniekiem, kuri saņēma divas Moderna mRNS-1273 vakcīnas devas [1]. Ar 11 no 13 asinis olbaltumvielas SARS-CoV-2 asinīs tika konstatētas tikai vienas dienas laikā pēc pirmās vakcīnas injekcijas.

NOZĪMĪGUMS:

Smaiļu olbaltumvielu molekulas tika ražotas šūnās, kas ir saskarē ar asinsriti – galvenokārt endotēlija šūnām – un izlaistas apgrozībā. Tas nozīmē, ka a) imūnsistēma uzbruks šīm endotēlija šūnām un b) cirkulējošās smailes proteīna molekulas aktivizēs trombocītus. Abi efekti veicinās asins recēšanu. Tas izskaidro daudzos ar recēšanu saistītos nevēlamos gadījumus – insultus, sirdslēkmes, vēnu trombozi -, par kuriem tiek bieži ziņots pēc vakcinācijas.

2. ATKLĀJUMS

Ātra atmiņas tipa antivielu reakcija pēc vakcinācijas: vairāki pētījumi ir parādījuši, ka cirkulējošās SARS-CoV-2 specifiskās IgG un IgA antivielas kļuva nosakāmas 1-2 nedēļu laikā pēc mRNS vakcīnu lietošanas [1–3].

NOZĪMĪGUMS:

Strauja IgG un IgA ražošana vienmēr norāda uz sekundāru, atmiņas tipa reakciju, kas rodas, atkārtoti stimulējot jau esošās imūnās šūnas. Primārās imūnās atbildes reakcijas uz jauniem antigēniem prasa ilgāku laiku, lai attīstītos, un sākotnēji ražo IgM antivielas, kam pēc tam seko izotipa pāreja uz IgG un IgA.

Dažos pētījumos blakus IgG un IgA patiešām tika noteikts noteikts daudzums IgM [1,4]. Tomēr ir svarīgi, ka IgG pieauga ātrāk nekā IgM [4], kas apstiprina, ka agrīnā IgG reakcija patiešām bija atmiņas tipa. Šī atmiņas reakcija norāda uz jau esošu, savstarpēji reaģējošu imunitāti, ko izraisījusi iepriekšēja inficēšanās ar parastajiem cilvēka elpošanas ceļu koronavīrusa celmiem. Novēlota IgM atbildes reakcija, visticamāk, ir primāra reakcija uz jauniem epitopiem, kas raksturīgi SARS-CoV-2.

Atmiņas tipa atbildes ir dokumentētas arī attiecībā uz imunitāti ar T-šūnu [5–7]. Kopumā šie atklājumi norāda, ka mūsu imūnsistēma efektīvi atpazīst SARS-CoV-2 kā “zināmu” pat pirmā kontakta laikā. Tādējādi smagus slimības gadījumus nevar attiecināt uz imunitātes trūkumu. Tā vietā smagus gadījumus ļoti labi var izraisīt vai saasināt jau esošā imunitāte, izmantojot uzlabojumus, kas atkarīgi no antivielām (ADE, skatīt zemāk).

3. ATKLĀJUMS

SARS-CoV-2 izraisa spēcīgas adaptīvas imūnās atbildes neatkarīgi no slimības smaguma pakāpes. Pēc SARS-CoV-2 infekcijas tika ziņots par seruma antivielu profiliem 203 indivīdiem [8]. 202 (>99%) dalībnieku parādījās SARS-CoV-2 specifiskas antivielas. Ar 193 indivīdiem (95%) šīs antivielas novērsa SARS-CoV-2 infekciju šūnu kultūrā un arī inhibēja smailes proteīna saistīšanos ar ACE2 receptoru. Turklāt CD8 + T-šūnu atbildes reakcijas, kas raksturīgas SARS-CoV-2, bija skaidras un kvantitatīvi nosakāmas 95 no 106 (90%) HLA-A2 pozitīvām personām.

NOZĪMĪGUMS:

Šis pētījums apstiprina iepriekš minēto apgalvojumu, ka imūnā atbilde uz sākotnējo kontaktu ar SARS-CoV-2 ir atmiņas tipa. Turklāt tas parāda, ka šī reakcija notiek gandrīz visiem indivīdiem, īpaši tiem, kuriem nav acīmredzamu klīnisku simptomu.

Vakcinācijas mērķis ir stimulēt antivielu veidošanos pret SARS-CoV-2, taču tagad mēs zinām, ka šādas antivielas ikviens var ātri ģenerēt pēc mazākās vīrusa izsaukšanas pat bez vakcinācijas.

Smagu plaušu infekciju attīstība vienmēr prasa daudzas dienas, kas nozīmē, ka, ja ir nepieciešamas atmiņas reakcijas radītās antivielas, tās ieradīsies laikā. Tādēļ maz ticams, ka vakcinācija sniegs ievērojamu labumu smagas plaušu infekcijas profilaksē.

4. ATKLĀJUMS

Strauja smailes olbaltumvielu un antivielu palielināšanās pēc otrās mRNS vakcīnu injekcijas. Pirms vakcinācijas un pēc pirmās un otrās mRNS vakcīnas injekcijas tika kontrolēti IgG un IgA antivielu titri [3]. Antivielu titri ar nelielu kavēšanos pēc pirmās injekcijas pieauga, pēc tam palielinājās, bet atkal neilgi pēc otrās injekcijas atkal pieauga.

NOZĪMĪGUMS:

Lai arī antivielu reakcija uz pirmo injekciju ir atmiņas tipa, nelielā laika nobīde pēc injekcijas var mazināt nevēlamās reakcijas, jo smailes proteīnu daudzums uz šūnām asinsvadu sieniņās un citos audos, iespējams, jau ir pagājis. maksimums, kad nonāk antivielas.

Ar otro injekciju situācija krasi mainās. Tad smailes tiek ražotas un novirzītas asinīs, kurās jau plūst gan reaktīvie limfocīti, gan antivielas. Antivielas izraisīs komplementa sistēmu [9,10] un arī neitrofilo granulocītu uzbrukumu olbaltumvielu nesošajām šūnām. Imūnās sistēmas visaptverošā pašnāvības iespējamās sekas ir biedējošas.

AUTOIMŪNĀ REAKCIJA

Kā aprakstīts, atmiņas tipa imūnās atbildes nodrošina ātru antivielu titru pieaugumu pēc sākotnējās SARS-CoV-2 iedarbības, padarot vakcīnas izraisītās antivielu atbildes priekšrocības ārkārtīgi apšaubāmas. Neatkarīgi no tā, nevajadzētu pieņemt, ka augsts antivielu titrs pret SARS-CoV-2 vienmēr uzlabos klīnisko rezultātu. Ar vairākām vīrusu ģimenēm – īpaši ar Denges vīrusa, bet arī ar koronavīrusiem – antivielas var saasināt, nevis mazināt slimību. Tas notiek tāpēc, ka noteiktas imūnsistēmas šūnas uzņem ar antivielām apzīmētus mikrobus un tos iznīcina.

Ja vīrusa daļiņu, kurai ir saistītas antivielas, uztver šāda šūna, bet pēc tam tai izdodas izvairīties no iznīcināšanas, tā vietā tā var sākt vairoties šūnā. Kopumā antivielas tad būs pastiprinājušas vīrusa replikāciju. Klīniski šī no antivielām atkarīgā uzlabošana (ADE) var izraisīt hiperiekaisuma reakciju (“citokīnu vētru”), kas pastiprinās plaušu, aknu un citu mūsu ķermeņa orgānu bojājumus.

Mēģinājumi izstrādāt vakcīnas pret sākotnējo SARS vīrusu, kas ir cieši saistīts ar SARS-CoV-2, ADE dēļ atkārtoti izgāzās. Vakcīnas inducēja antivielas, bet, kad vakcinētie dzīvnieki pēc tam tika inficēti ar vīrusu, viņi saslima vairāk nekā nevakcinētie kontrolieri (sk., Piemēram, [11]). Klīniskajos pētījumos ar kādu no COVID-19 vakcīnām ADE iespējamība netika pienācīgi ņemta vērā. Tāpēc ir saprātīgi izvairīties no ADE izraisīšanas draudiem ar vakcināciju un tā vietā paļauties uz pārbaudītām ārstēšanas formām [12], lai risinātu klīniski smagu COVID-19 slimību.

SECINĀJUMS

Iepriekš apspriestie kolektīvie atklājumi skaidri parāda, ka vakcinācijas priekšrocības ir ļoti apšaubāmas. Turpretim vakcīnu nodarītais kaitējums ir ļoti labi pamatots, un vairāk nekā 15 000 ar vakcināciju saistītie nāves gadījumi tagad ir dokumentēti ES zāļu nevēlamo notikumu datubāzē (EudraVigilance) un vairāk nekā 7 000 nāves gadījumu Apvienotajā Karalistē un ASV [13].

VISIEM PRAKTIZĒJOŠIEM ĀRSTIEM IR JĀPĀRSKATA ĒTISKIE JAUTĀJUMI SAISTĪBĀ AR COVID-19 VAKCINĀCIJU.

Atsauces
1. Ogata, A.F. et al. (2021) Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. Clin. Infect. Dis. -:x-x (www.ncbi.nlm.nih.gov/pmc/articles/PMC8241425/ )
2. Amanat, F. et al. (2021) SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD and S2. Cell -:x-x (www.sciencedirect.com/science/article/pii/S0092867421007066 )
3. Wisnewski, A.V. et al. (2021) Human IgG and IgA responses to COVID-19 mRNA vaccines. PLoS One 16:e0249499 (journals.plos.org/plosone/article?id=10.1371/journal.pone.0249499 )
4. Qu, J. et al. (2020) Profile of Immunoglobulin G and IgM Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin. Infect. Dis. 71:2255-2258 (pubmed.ncbi.nlm.nih.gov/32337590/ )
5. Le Bert, N. et al. (2020) SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature 584:457-462 (www.nature.com/articles/s41586-020-2550-z )
6. Grifoni, A. et al. (2020) Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Cell 181:1489-1501.e15 (pubmed.ncbi.nlm.nih.gov/32473127/ )
7. Gallais, F. et al. (2021) Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion. Emerg. Infect. Dis. 27:x-x (wwwnc.cdc.gov/eid/article/27/1/20-3611_article )
8. Nielsen, S.S. et al. (2021) SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity. EBioMedicine 68:103410 (www.thelancet.com/pdfs/journals/ebiom/PIIS2352-3964(21)00203-6.pdf )
9. Magro, C.M. et al. (2020) Docked severe acute respiratory syndrome coronavirus 2 proteins within the cutaneous and subcutaneous microvasculature and their role in the pathogenesis of severe coronavirus disease 2019. Hum. Pathol. 106:106-116 (pubmed.ncbi.nlm.nih.gov/33058948/ )
10. Magro, C.M. et al. (2021) Severe COVID-19: A multifaceted viral vasculopathy syndrome. Annals of diagnostic pathology 50:151645 (www.sciencedirect.com/science/article/abs/pii/S109291342030191X?via%3Dihub )
11. Tseng, C. et al. (2012) Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus. PLoS One 7:e35421 (pubmed.ncbi.nlm.nih.gov/22536382/ )
12. McCullough, P.A. et al. (2021) Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection. Am. J. Med. 134:16-22 (www.ncbi.nlm.nih.gov/pmc/articles/PMC7410805/ )
13. Johnson, L. (2021) Official Vaccine Injury and Fatality Data: EU, UK and US (doctors4covidethics.org/official-eu-adverse-event-data-eu-uk-us/ ).

“Pietiek lasītājs”
/25.07.2021/

Avots:
www.pietiek.com/raksti/vestule_arstiem/

[Šis ir viens no nozīmīgākajiem zinātniskajiem tekstiem latviešu valodā par Covid-19, kuru ir uzrakstījis kāds autoratīvs ārsts. Par to liecina teksta valoda, stils, kopējā loģika un tonis. Šo tekstu uzrakstījušais cilvēks ļoti labi pārzin medicīniskus terminus, prot konstruktīvi izteikties, bez nevajadzīgas liekvārdības pasakot galveno, ir korekts savos izteikumos un pamato tos saskaņā ar zinātniskā izklāsta formas prasībām, kā arī ir pieradis pie tā, ka viņa viedoklī ieklausās.

Dotais teksts ir šāda cilvēka noteikta ilguma zinātnisko pārdomu, novērojumu un personiskās izpētes rezultāts, ar ko viņš steidz padalīties ar kolēģiem un sabiedrību tad, kad pats ir nonācis līdz zinātniski pamatotai pārliecībai par sakāmo, un apstākļos, kad mazāk kompetenti cilvēki (daļa no kuriem visticamāk ir arī negodprātīgi) pieļauj nopietnu kļūdu, grasoties to vēl pastiprināt, kas daudziem cilvēkiem var maksāt dzīvību.

Diemžēl viņš to dara anonīmi, kas tomēr ir saprotams, jo Nacionālais veselības dienests (NVD) jau atklāti ir paziņojis par vēršanos pret medicīnas sfērā strādājošajiem, kuri publiski apšauba vakcinācijas pret Covid-19 lietderības dogmu. Tai pat laikā teksts liecina arī par to, ka anonimitāte tā autoram nav principiāla (viņš necer šādos apstākļos ilgstoši palikt “savā vietā” un nebaidās no galma ierēdņu un žurnālistu iespējamā mobinga un represijām) un ka pie noteiktiem apstākļiem viņš to pašu ir gatavs pateikt arī publiski zem sava vārda, un to nedara tikai tādēļ, ka uzskata, ka pagaidām šādi būs labāk.]


/29.07.2021/

Anonīma ārsta vēstule kolēģiem par masu vakcinācijas pret Covid-19 neviennozīmīgumu

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354 thoughts on “Anonīma ārsta vēstule kolēģiem par masu vakcinācijas pret Covid-19 neviennozīmīgumu

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